- S. Craig Zahler
- S. Leigh Savidge
- S.J. Perelman
- S.Z. Sakall
- Sab Shimono
- Sabine Azéma
- Sabine Haudepin
- Sabotage
- Sabrina Greve
- Sabrina Impacciatore
- Sabrina Ouazani
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- Sabu
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- Sacha Baron Cohen
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- Sachiko Hidari
- Sachio Sakai
- Sadako Sawamura
- Sadi Cabral
- Sadie Sink
- Saeed Jaffrey
- Sahajak Boonthanakit
- Saïd Taghmaoui
- Saif Ali Khan
- Sakae Umezu
- Sakda Kaewbuadee
- Sakichi Satô
- Sakina Jaffrey
- Sakura Andô
- Sal Mineo
- Salli Richardson-Whitfield
- Sallie Harmsen
- Sally Benson
- Sally Field
- Sally Hawkins
- Sally Kellerman
- Sally Kirkland
- Sally Phillips
- Sally Potter
- Sally Struthers
- Sally Yeh
- Salma Hayek
- Salmaan Peerzada
- Salman Khan
- Salvador Dalí
- Salvatore Borghese
- Salvatore Cascio
- Salvatore Puntillo
- Salvo Randone
- Sam Anderson
- Sam Bottoms
- Sam Claflin
- Sam Douglas
- Sam Elliott
- Sam Firstenberg
- Sam Hazeldine
- Sam Hobkinson
- Sam Huntington
- Sam J. Jones
- Sam Jaffe
- Sam Keeley
- Sam Kydd
- Sam Laws
- Sam McMurray
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- Sam Pillsbury
- Sam Raimi
- Sam Reid
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- Sam Riley
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- Sam Shepard
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- Sam Trammell
- Sam Wanamaker
- Sam Waterston
- Sam Wood
- Sam Worthington
- Samantha Bee
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- Samantha Mathis
- Samantha Morton
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- Sanaa Lathan
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- Sandahl Bergman
- Sandra Bréa
- Sandra Bullock
- Sandra Corveloni
- Sandra Dee